|Title:||Evolution in Cancer|
|Group/Series/Folder:||Record Group 8.15 - Institute for Advanced Study|
Series 3 - Audio-visual Materials
|Location:||8.15:3 box 1.4|
|Notes:||Institute for Advanced Study Workshop: Evolution: Foundations, Fundamentals, and Disease. Session 4: The role of evolution in biological disease: Cancer and cell dynamics.|
Abstract: Our current theory of carcinogenesis is that mutant clones arise through genetic or epigenetic instability, and if they have a reproductive or survival advantage over other cells in the tumor, within their microenvironment, they will expand in the tumor in a selective sweep. Thus, we believe carcinogenesis is characterized by a series of selective sweeps. However, virtually all data on that process to date is cross‐sectional, with observations of genetic diversity and large clonal expansions within neoplasms at a single time point.
Duration: 51 min.
|Appears in Series:||8.15:3 - Audio-visual Materials|
Videos for Public -- Distinguished Lectures