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Title: Leptin and the Biologic Basis of Obesity: Homeostatic Control of Body Weight, the Cloning of the Ob Gene and the Identification of Leptin, Clinical Implications
Originating Office: OUDPA
Speaker: Friedman, Jeffrey M
Issue Date: 8-Oct-2009
Event Date: 8-Oct-2009
Group/Series/Folder: Record Group 3.8 - Office of University Development and Public Affairs
Series 6 - Audio-visual Materials
Location: 3.8:6 EF
Notes: Shaw Prize Lecture in Life Science and Medicine.
Abstract: Recessive mutations in the leptin gene are associated with massive obesity in mice and some humans. Treatment with recombinant leptin markedly reduces food intake and body weight. The low leptin levels in patients with leptin mutations are also associated with multiple abnormalities including infertility, diabetes and immune abnormalities all of which are corrected by leptin treatment. These findings have established important links between energy stores and many other physiologic systems and led to the use of leptin as a treatment for an increasing number of other human conditions including a subset of obesity, some forms of diabetes including lipodystrophy and hypothalamic amennorhea, the cessation of menstruation seen in extremely thin women. Identification of a physiologic system that controls energy balance establishes a biologic basis for obesity and further establishes links between leptin and numerous other physiologic responses.
Jeffrey M Friedman, born 1954 in Orlando, Florida, is currently Marilyn M Simpson Professor of The Rockefeller University and Investigator of the Howard Hughes Medical Institute. He earned his medical degree from Albany Medical College of Union University in 1976 and his PhD from the Rockefeller University in 1986. He is a member of the US National Academy of Sciences and the Institute of Medicine.
Duration: 55 min.
Appears in Series:3.8:6 - Audio-visual Materials
Videos for Public -- Distinguished Lectures